SidaGhanaV1, Main, Exploration, bibRecord, 001088

Estimated risk of HIV transmission by blood transfusion in Kenya

Identifieur interne : 001088 ( Main/Exploration ); précédent : 001087; suivant : 001089

Estimated risk of HIV transmission by blood transfusion in Kenya

Auteurs : Anne Moore [États-Unis] ; Guillermo Herrera [États-Unis] ; Jack Nyamongo [Kenya] ; Eve Lackritz [États-Unis] ; Tim Granade [États-Unis] ; Bernard Nahlen [États-Unis] ; Aggrey Oloo [Kenya] ; George Opondo [Kenya] ; Richard Muga [Kenya] ; Robert Janssen [États-Unis]

Source :

The Lancet [ 0140-6736 ] ; 2001.

RBID : ISTEX:3B001902E0BAD6D046BEF7F7FDBAEF9E149557B1

Descripteurs français

Wicri :
- geographic : Kenya.
- topic : Transfusion sanguine, Don, Santé publique.

English descriptors

Abstract

Background During the past decade, developing countries have received limited support for blood safety programmes. The Kenya Ministry of Health did a collaborative multicentre assessment to establish the risk of HIV transmission by transfusion in Kenya, to promote awareness of blood safety issues in this country with a mature HIV epidemic, and to identify methods to reduce the risk of HIV transmission by blood transfusion in Kenya.Methods For 12 weeks, from April to July 1994, we collected information and blood samples from all blood donors, and pretransfusion samples were collected from all recipients in six government hospitals in Kenya. Blood donations were collected and screened for HIV according to standard practice in the hospital laboratories. Test results at a reference laboratory were compared with those of the hospital laboratories and risk of transfusion-associated HIV transmission was calculated.Findings The prevalence of HIV among blood donors was 64 (120 of 1877) and varied by hospital (range 220). HIV test results were available for 1290 donor-recipient pairs. Of these, 26 HIV-positive donations were given to HIV-negative patients. We estimate that 20 of transfusions transmitted HIV. Problems in the hospitals that contributed to transfusion risk included inconsistent refrigeration, data entry errors, equipment failure, and lack of a quality-assurance programme.Interpretation A high proportion of blood transfusions transmitted HIV in this high-prevalence area of Africa, primarily because of erroneous laboratory practices. On the basis of these results, the Kenya Ministry of Health introduced a number of practical and inexpensive interventions to improve national blood safety.

Url:

https://api.istex.fr/document/3B001902E0BAD6D046BEF7F7FDBAEF9E149557B1/fulltext/pdf

DOI: 10.1016/S0140-6736(01)05783-X

Affiliations:

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Le document en format XML

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<author><name sortKey="Herrera, Guillermo" sort="Herrera, Guillermo" uniqKey="Herrera G" first="Guillermo" last="Herrera">Guillermo Herrera</name>
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<author><name sortKey="Granade, Tim" sort="Granade, Tim" uniqKey="Granade T" first="Tim" last="Granade">Tim Granade</name>
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<author><name sortKey="Oloo, Aggrey" sort="Oloo, Aggrey" uniqKey="Oloo A" first="Aggrey" last="Oloo">Aggrey Oloo</name>
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<author><name sortKey="Janssen, Robert" sort="Janssen, Robert" uniqKey="Janssen R" first="Robert" last="Janssen">Robert Janssen</name>
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<wicri:regionArea>Correspondence to: Dr Robert S Janssen, Division of HIV/AIDS Prevention-Surveillance and Epidemiology, Centers for Disease Control and Prevention, Atlanta, GA 30333</wicri:regionArea>
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<series><title level="j">The Lancet</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bernard nahlen</term>
<term>Blood donations</term>
<term>Blood donors</term>
<term>Blood safety</term>
<term>Blood safety issues</term>
<term>Blood samples</term>
<term>Blood screening</term>
<term>Blood supply</term>
<term>Blood transfusion</term>
<term>Blood transfusion practices</term>
<term>Blood transfusions</term>
<term>Collaborative multicentre assessment</term>
<term>Disease control</term>
<term>Donation</term>
<term>Donor</term>
<term>Family donors</term>
<term>George opondo</term>
<term>Government hospitals</term>
<term>Guillermo herrera</term>
<term>Hospital laboratories</term>
<term>Kenya</term>
<term>Kenya ministry</term>
<term>Kenyan hospital</term>
<term>Kit</term>
<term>Laboratory practices</term>
<term>Lancet</term>
<term>Lancet publishing group</term>
<term>Many areas</term>
<term>Medical records</term>
<term>National blood transfusion service</term>
<term>National center</term>
<term>Other countries</term>
<term>Programme</term>
<term>Public health</term>
<term>Quality assurance</term>
<term>Rapid assessment</term>
<term>Reference laboratory</term>
<term>Reference laboratory testing</term>
<term>Research institute</term>
<term>Richard muga</term>
<term>Risk factors</term>
<term>Standard practice</term>
<term>Study period</term>
<term>Study team</term>
<term>Test kits</term>
<term>Test result</term>
<term>Test results</term>
<term>Transfusion</term>
<term>Transfusion risk</term>
<term>Volunteer donors</term>
<term>Western kenya</term>
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<keywords scheme="Teeft" xml:lang="en"><term>Bernard nahlen</term>
<term>Blood donations</term>
<term>Blood donors</term>
<term>Blood safety</term>
<term>Blood safety issues</term>
<term>Blood samples</term>
<term>Blood screening</term>
<term>Blood supply</term>
<term>Blood transfusion</term>
<term>Blood transfusion practices</term>
<term>Blood transfusions</term>
<term>Collaborative multicentre assessment</term>
<term>Disease control</term>
<term>Donation</term>
<term>Donor</term>
<term>Family donors</term>
<term>George opondo</term>
<term>Government hospitals</term>
<term>Guillermo herrera</term>
<term>Hospital laboratories</term>
<term>Kenya</term>
<term>Kenya ministry</term>
<term>Kenyan hospital</term>
<term>Kit</term>
<term>Laboratory practices</term>
<term>Lancet</term>
<term>Lancet publishing group</term>
<term>Many areas</term>
<term>Medical records</term>
<term>National blood transfusion service</term>
<term>National center</term>
<term>Other countries</term>
<term>Programme</term>
<term>Public health</term>
<term>Quality assurance</term>
<term>Rapid assessment</term>
<term>Reference laboratory</term>
<term>Reference laboratory testing</term>
<term>Research institute</term>
<term>Richard muga</term>
<term>Risk factors</term>
<term>Standard practice</term>
<term>Study period</term>
<term>Study team</term>
<term>Test kits</term>
<term>Test result</term>
<term>Test results</term>
<term>Transfusion</term>
<term>Transfusion risk</term>
<term>Volunteer donors</term>
<term>Western kenya</term>
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<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Kenya</term>
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<front><div type="abstract">Background During the past decade, developing countries have received limited support for blood safety programmes. The Kenya Ministry of Health did a collaborative multicentre assessment to establish the risk of HIV transmission by transfusion in Kenya, to promote awareness of blood safety issues in this country with a mature HIV epidemic, and to identify methods to reduce the risk of HIV transmission by blood transfusion in Kenya.Methods For 12 weeks, from April to July 1994, we collected information and blood samples from all blood donors, and pretransfusion samples were collected from all recipients in six government hospitals in Kenya. Blood donations were collected and screened for HIV according to standard practice in the hospital laboratories. Test results at a reference laboratory were compared with those of the hospital laboratories and risk of transfusion-associated HIV transmission was calculated.Findings The prevalence of HIV among blood donors was 64 (120 of 1877) and varied by hospital (range 220). HIV test results were available for 1290 donor-recipient pairs. Of these, 26 HIV-positive donations were given to HIV-negative patients. We estimate that 20 of transfusions transmitted HIV. Problems in the hospitals that contributed to transfusion risk included inconsistent refrigeration, data entry errors, equipment failure, and lack of a quality-assurance programme.Interpretation A high proportion of blood transfusions transmitted HIV in this high-prevalence area of Africa, primarily because of erroneous laboratory practices. On the basis of these results, the Kenya Ministry of Health introduced a number of practical and inexpensive interventions to improve national blood safety.</div>
</front>
</TEI>
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<li>États-Unis</li>
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<region><li>Géorgie (États-Unis)</li>
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<name sortKey="Granade, Tim" sort="Granade, Tim" uniqKey="Granade T" first="Tim" last="Granade">Tim Granade</name>
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<name sortKey="Janssen, Robert" sort="Janssen, Robert" uniqKey="Janssen R" first="Robert" last="Janssen">Robert Janssen</name>
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<name sortKey="Nahlen, Bernard" sort="Nahlen, Bernard" uniqKey="Nahlen B" first="Bernard" last="Nahlen">Bernard Nahlen</name>
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<country name="Kenya"><noRegion><name sortKey="Nyamongo, Jack" sort="Nyamongo, Jack" uniqKey="Nyamongo J" first="Jack" last="Nyamongo">Jack Nyamongo</name>
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Le SIDA au Ghana (serveur d'exploration)

Estimated risk of HIV transmission by blood transfusion in Kenya

Estimated risk of HIV transmission by blood transfusion in Kenya

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri